Prednisolone Co-Administered with Losartan Confers Renoprotection in Patients with IgA Nephropathy

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Prednisolone Co-Administered with Losartan Confers Renoprotection in Patients with IgA Nephropathy

BACKGROUND Treatment options for progressive IgA nephropathy are limited. METHODS We performed a small, randomized controlled trial to evaluate the effects of prednisolone (PSL, 30 mg/dL, gradually tapered to 5 mg/dL over two years) plus 50 mg/day of losartan (LST, an angiotensin II receptor blocker) or PSL alone on IgA nephropathy. We separated 38 patients (age, 33 +/- 11 years; creatinine c...

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Optimal Proteinuria Target for Renoprotection in Patients with IgA Nephropathy

BACKGROUND Proteinuria is a target for renoprotection in kidney diseases. However, optimal level of proteinuria reduction in IgA nephropathy (IgAN) is unknown. METHODS We conducted a retrospective observational study in 500 patients with biopsy-proven IgAN. Time-averaged proteinuria (TA-P) was calculated as the mean of every 6 month period of measurements of spot urine protein-to-creatinine r...

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Patients with IgA Nephropathy

The actual state of IgA nephropathy in Japan was surveyed throughout the nation by a questionnaire. Five hundred patients were collected from 26 departments of pediatrics and 2,1 75 from 27 internal medicine. IgA nephropathy accounted for 19.2% of the children and 30.0% of the adults among primary glomerular diseases. Most of the patients, regardless children and adults, were detected by chance...

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Optimal dose of losartan for renoprotection in diabetic nephropathy.

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ژورنال

عنوان ژورنال: Renal Failure

سال: 2007

ISSN: 0886-022X,1525-6049

DOI: 10.1080/08860220701260511